Using Transcranial Alternating Current Stimulation to Improve Executive Function in 22q11.2 Deletion Syndrome

Recruiting now · Not applicable · Has a placebo group

Conditions studied: 22Q11 Deletion Syndrome, tACS

In brief

The purpose of this project is to explore the effects of transcranial alternating current stimulation (tACS) in children, adolescents and young adults with a 22q11.2 microdeletion. The main aim of the present research project is to investigate the effects of repeated, individually tuned high-density (HD) tACS on cognition (i.e., WM performance) and related neuroimaging markers in carriers of the 22q11DS. As cognitive deficits, most notably WM impairment, are among the earliest signs of psychotic disorders, interventions during adolescence aimed at reducing cognitive decline in at-risk individuals may prove effective in delaying or even preventing the later emergence of psychotic symptoms.

Key facts

Study ID

NCT05664412

Run by

Stephan Eliez

People needed

40

Starts

2023-10-20

Expected to finish

2026-12-31

Last updated by the study team

2025-12-02

Who can join

Age: 14 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed genetic diagnosis of 22q11DS
• Age between 14 and 25 years old
• Willingness to participate
• Informed Consent signed by the subject and/or the caregiver(s)

You may not qualify if…

• Epilepsy
• Deep brain stimulation electrodes
• Traumatic brain injury
• Facial metal implants

Where it is running

• University of Geneva — Geneva, Canton of Geneva, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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