A Study to Evaluate the Pharmacokinetics and Safety of Loncastuximab Tesirine in Participants With Relapsed or Refractory Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma With Hepatic Impairment (LOTIS-10)
Stopped early · Phase 1
Conditions studied: Diffuse Large B-Cell Lymphoma, High-grade B-cell Lymphoma
In brief
The primary objective of this study is to determine the recommended dosing regimen of loncastuximab tesirine in diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell lymphoma (HGBCL) participants with moderate and severe hepatic impairment.
Key facts
- Study ID
- NCT05660395
- Run by
- ADC Therapeutics S.A.
- People needed
- 5
- Starts
- 2023-07-28
- Expected to finish
- 2026-06-25
- Last updated by the study team
- 2026-07-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female participants aged 18 years or older
- Pathologic diagnosis of relapsed (disease that has recurred following a response) or refractory (disease that failed to respond to prior therapy) DLBCL not otherwise specified, DLBCL arising from low grade lymphoma, and high-grade B-cell lymphoma (2016 World Health Organization classification) who have received at least one systemic treatment regimen
- Measurable disease as defined by the 2014 Lugano Classification
- Normal hepatic function or hepatic impairment as defined by the National Cancer Institute Organ Dysfunction Working Group hepatic impairment classification:
- Arm A Normal hepatic function: bilirubin and aspartate aminotransferase (AST) ≤ upper limit of normal (ULN)
- Arm B Moderate hepatic impairment: bilirubin > 1.5 × to 3 × ULN (any AST)
- Arm C Severe hepatic impairment: bilirubin > 3 × ULN (any AST)
- ECOG performance status 0 to 2 for participants with normal hepatic function. ECOG 0 to 3 for participants with moderate or severe hepatic impairment
- Adequate organ function
- Women of childbearing potential (WOCBP)* must agree to use a highly effective method of contraception from the time of giving informed consent until at least 10 months after the last dose of study drug. Men with female partners who are of childbearing potential must agree to use a condom when sexually active or practice total abstinence from the time of the first dose until at least 7 months after the last dose of study drug.
You may not qualify if…
- Previous therapy with loncastuximab tesirine
- Allogenic or autologous stem cell transplant within 60 days prior to start of study drug (C1D1)
- Human immunodeficiency virus (HIV) seropositive
- Serologic evidence of chronic hepatitis B virus (HBV) infection and unable or unwilling to receive standard prophylactic antiviral therapy or with detectable HBV viral load
- Serologic evidence of hepatitis C virus (HCV) infection without completion of curative treatment or with detectable HCV viral load
- History of Stevens-Johnson syndrome or toxic epidermal necrolysis
- Lymphoma with active central nervous system involvement at the time of screening, including leptomeningeal disease
- Breastfeeding or pregnant
- Significant medical comorbidities
- Major surgery, radiotherapy, chemotherapy, or other anti-neoplastic therapy, within 14 days prior to start of study drug (C1D1), except shorter if approved by the Sponsor
Where it is running
- The Oncology Institute of Hope & Innovation - Lynwood — Lynwood, California, United States
- Hospital Sírio-Libanês - Brasília — Brasília, Brazil
- Hospital Mãe de Deus - Centro Integrado de Oncologia — Porto Alegre, Brazil
- Hospital Sírio-Libanês - São Paulo — São Paulo, Brazil
- A Beneficência Portuguesa de São Paulo - Unidade Mirant — São Paulo, Brazil
- Hospital 9 de Julho — São Paulo, Brazil
- Albert Einstein Israelite Hospital — São Paulo, Brazil
- Kyungpook National University Chilgok Hospital — Daegu, Daegu Gwang'yeogsi, South Korea
- Dong-A University Hospital — Pusan, Gyeongsangnam-do, South Korea
- Korea University Anam Hospital — Seoul, Seongbuk District, South Korea
- Seoul National University Hospital — Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], South Korea
- Severance Hospital — Seoul, Seoul Teugbyeolsi, South Korea
- National Taiwan University Hospital — Taipei, Taiwan
- Koo Foundation Sun Yat-Sen Cancer Center — Taipei, Taiwan
Full record on ClinicalTrials.gov
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