Prognostic Role of the Uremic Toxin Indoxyl Sulfate on Vascular and Cardiac Functions During Acute Kidney Injury

Recruiting now · Not applicable

Conditions studied: Acute Kidney Injury, Uremic; Toxemia, Vascular Dysfunction, Cardiac Dysfunction, Cardiovascular Prognosis

In brief

Acute kidney injury (AKI) is a frequent disease in conventional hospital departments and in intensive care units. It's associated with a high risk to develop chronic kidney disease (CKD), even after a single small AKI episode. It's also associated with an important morbi-mortality, particularly cardiovascular (CV). Some studies have already showed a link between AKI and CV risk but pathologic mechanisms implicated are still unknown. In AKI and CKD, numerous substances, called uremic toxins (UT) are accumulating in blood. In CKD, those toxins, and particularly Indoxyl sulfate (IS), are known to have cardiac and vascular deleterious consequences. However, in AKI, whether acute accumulation of UT may trigger CV complications is unknown. The purpose of this study is that during AKI, a high UT concentration, in particular IS, would be associated with early vascular and cardiac dysfunctions that can be characterized by the persistence of an accelerated pulse wave velocity (PWV). The main objective is to evaluate the correlation between UT concentrations (especially IS) and arterial stiffness (PWV measurement) at three months of an AKI episode in conventional hospital departments and in the intensive care unit of nephrology.

Key facts

Study ID

NCT05659589

Run by

Centre Hospitalier Universitaire, Amiens

People needed

105

Starts

2022-12-13

Expected to finish

2026-06-01

Last updated by the study team

2025-05-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age over 18 years old.
• Patients hospitalized in conventional hospital departments and in intensive care units of nephrology.
• Patients with moderate to severe AKI (KDIGO 2 or 3) without dialysis.
• AKI from functional or organic aetiology

You may not qualify if…

• Patients with severe CKD (GFR<45ml/min/1.73 m2) or with kidney transplants.
• Patients with AKI from septic or obstructive aetiology.
• Patients with AKI from toxic aetiology whose toxic would be also responsable of cardia toxicity.
• Patients with sepsis or blood inflammation.
• Patients with severe chronic cardia dysfunction.
• Patients with arrhythmia or complete heart block.
• Patients with peripheral artery occlusive disease.
• Pregnancy.
• Patients on palliative care.

Where it is running

• Amiens hospital — Amiens, France (enrolling)

Full record on ClinicalTrials.gov

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