Reducing Acute Upper Gastrointestinal Side-Effects of Thoracic Irradiation

Running, not enrolling · Phase 2

Conditions studied: Radiation Esophagitis

In brief

The purpose of the study is to explore options for preventing and reducing symptoms of radiation esophagitis (RE). The researchers will also look what symptoms participants experience, and whether there are differences in weight loss in participants.

Key facts

Study ID

NCT05659576

Run by

Memorial Sloan Kettering Cancer Center

People needed

142

Starts

2022-12-13

Expected to finish

2026-12-01

Last updated by the study team

2026-01-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients being treated with thoracic irradiation with high-risk esophageal dose as determined below:
• Esophageal dose:
• V50 ≥ 15% (25-35 once daily fractions) or 40 twice-daily [BID] fractions)
• V40 ≥ 15% (15-24 once daily fractions or 30 twice-daily [BID] fractions)
• V30 ≥ 15% (10-14 once daily fractions)
• Age 18 years of age or older.

You may not qualify if…

• Known inability to take Sucralfate (tablet and/or suspension form), per physician discretion
• PEG tube
• Actively taking any opioid pain medications prior to radiation therapy
• History of an opioid use disorder

Where it is running

• Memorial Sloan Kettering Cancer Center Basking Ridge (All Protocol Activities) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth (All Protocol Activities) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (All Protocol Activities) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities ) — Commack, New York, United States
• Memorial Sloan Kettering Westchester (All Protocol Activities) — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States
• Memorial Sloan Kettering Nassau (All Protocol Activities) — Uniondale, New York, United States

Full record on ClinicalTrials.gov

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