APOL1 Genetic Testing in African Americans
Recruiting now
Conditions studied: Genetic Predisposition, Chronic Kidney Diseases, Nephropathy, APOL1 Associated Kidney Disease, Disparities
In brief
Recent breakthroughs in medical genetics have discovered that a portion of kidney failure affecting the Black community is mediated by coding variants in a gene called apolipoprotein L1 (APOL1) - and that genetic variants, not race - account for increased risk. For APOL1 genetic testing to be applied in a manner that improves patient care and outcomes, more information is needed regarding associations of genotype with clinical parameters related to kidney health. Further, understanding patient perceptions about knowledge of the results of APOL1 genetic testing, and how that impacts patient engagement with management of hypertension and other renal risk factors, is urgently needed. * In a Phase 1 pilot study, we offered APOL1 genetic testing to Black patients seen in our Hypertension and Nephrology clinics at Saint Louis University, an academic medical center that serves the local urban community, and surveyed patients on attitudes and concerns about APOL1 genetic testing. 144 participants were enrolled in Phase 1. * In the Phase 2 study, we will advance this important work in our community by offering participation to a broader patient base, including patients seen in Internal and Family Medicine clinics, SLU Hospital, as well as to first-degree relatives and spouses of SLUCare participants. This expansion seeks to advance understanding of environment-gene interactions, improve risk prediction, and target management of potentially modifiable risk factors.
Key facts
- Study ID
- NCT05656261
- Run by
- St. Louis University
- People needed
- 600
- Starts
- 2019-01-24
- Expected to finish
- 2027-06-30
- Last updated by the study team
- 2025-03-20
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ages 18-90
- Self-Identified as Black/African American. Race will be self-identified. Patients of African ancestry who identify as multi-racial are also eligible to participate.
You may not qualify if…
- Cognitively impaired/unable to provide consent
- Terminally ill
- Renal replacement therapy (RRT), e.g., (but not limited to) hemodialysis, peritoneal dialysis
Where it is running
- SSM Health Saint Louis University Hospital — St Louis, Missouri, United States (enrolling)
Full record on ClinicalTrials.gov
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