VTX958 Versus Placebo for the Treatment of Moderate to Severe Psoriasis

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Psoriasis

In brief

This is a study to understand if taking VTX958 is safe and effective in participants diagnosed with moderate to severe psoriasis (PsO). Approximately 200 patients will take VTX958 Dose A, VTX958 Dose B, VTX958 Dose C, VTX958 Dose D, or placebo. The study consists of a 30-day Screening Period (to see if a participant qualifies for the study), a 16-week double-blind period (a participant receives active Dose A, Dose B, Dose C, Dose D, or placebo), a 16-week Long Term Extension (LTE) period, a 36-week Open Label Extension (OLE) period and a 4-week Follow-Up Period. The maximal duration of treatment will be approximately 16 months.

Key facts

Study ID: NCT05655299
Run by: Ventyx Biosciences, Inc
People needed: 222
Starts: 2022-11-17
Expected to finish: 2023-12-20
Last updated by the study team: 2024-09-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Male or female participant aged 18 years or older.
History of primarily plaque psoriasis for at least 6 months prior to the screening visit.
Has had stable psoriasis conditions for at least 3 months before screening.
Has moderate to severe plaque psoriasis as defined by a PASI score of ≥ 12 and an sPGA score of ≥ 3 at screening and Day 1.
Has plaque psoriasis covering ≥ 10% of the total BSA at screening and Day 1.
Deemed by the investigator to be eligible for phototherapy or systemic therapy.
Females of childbearing potential must agree to use a highly effective contraceptive method from at least 4 weeks prior to Day 1 until at least 4 weeks after the last dose of study product.

You may not qualify if…

Female who is breastfeeding, pregnant, lactating, or who is planning to become pregnant during the study.
Has evidence of erythrodermic, pustular, predominantly inverse or guttate psoriasis, or drug-induced psoriasis.
History of skin disease or presence of skin condition that, in the opinion of the investigator, would interfere with the study assessments.
Participant is known to have immune deficiency or is immunocompromised.
Has immune-mediated conditions commonly associated with psoriasis, such as psoriatic arthritis, active uveitis, inflammatory bowel disease, that currently require systemic treatment (including corticosteroids, immunosuppressants, or biologics).
Note: Participants with immune-mediated conditions commonly associated with psoriasis that do not require systemic treatment may be included in the study.
Has used any topical medication that could affect psoriasis (including corticosteroids, retinoids, vitamin D analogues [such as calcipotriol], Janus kinase [JAK] inhibitors, or tar) within 2 weeks prior to Day 1.
Has used any systemic treatment that could affect psoriasis (including corticosteroids, oral retinoids, immunosuppressive medication, anakinra, methotrexate, cyclosporine, oral JAK inhibitors, or apremilast) within 4 weeks prior to Day 1.
Note: Intranasal corticosteroids and inhaled corticosteroids are allowed. Eye and ear drops containing corticosteroids are also allowed.
Participant has received any ultraviolet B (UVB) phototherapy (including tanning beds) or excimer laser within 4 weeks prior to Day 1.
Participant has had psoralen and ultraviolet A (PUVA) treatment within 4 weeks prior to Day 1.
Participant has received treatment with an investigational or marketed TYK2 inhibitor.

Where it is running

Local Site # 840006 — Birmingham, Alabama, United States
Local Site # 840028 — Phoenix, Arizona, United States
Local Site # 840032 — Bryant, Arkansas, United States
Local Site # 840041 — North Little Rock, Arkansas, United States
Local Site # 840031 — Fountain Valley, California, United States
Local Site # 840026 — Lomita, California, United States
Local Site # 840019 — Santa Rosa, California, United States
Local Site # 840003 — Sherman Oaks, California, United States
Local Site # 840040 — Boca Raton, Florida, United States
Local Site # 840011 — Doral, Florida, United States
Local Site # 840023 — Hialeah, Florida, United States
Local Site # 840021 — Miami Lakes, Florida, United States
Local Site # 840044 — North Miami Beach, Florida, United States
Local Site # 840010 — Ocala, Florida, United States
Local Site # 840004 — Tampa, Florida, United States
Local Site # 840001 — Tampa, Florida, United States
Local Site # 840045 — West Palm Beach, Florida, United States
Local Site # 840029 — Marietta, Georgia, United States
Local Site # 840035 — Clarksville, Indiana, United States
Local Site # 840005 — Indianapolis, Indiana, United States
Local Site # 840030 — Plainfield, Indiana, United States
Local Site # 840013 — Louisville, Kentucky, United States
Local Site # 840022 — Rockville, Maryland, United States
Local Site # 840008 — Brighton, Massachusetts, United States
Local Site # 840012 — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.