Development of CIRC Technologies

Recruiting now

Conditions studied: Cardiovascular Diseases, Heart Failure, Ischemic Heart Disease, Non-ischemic Cardiomyopathy, Valvular Heart Disease, Metabolic Cardiomyopathy, Congenital Heart Disease, Aortic Diseases, Atrial Fibrillation, Ventricular Fibrillation

In brief

Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiomyopathy, such as amyloid. However, there is a lack of agreement of on which markers are the most sensitive. This multi-study will allow us the unique opportunity to form a more comprehensive understanding for various cardiovascular diseases. Our team has developed novel cardiac MRI techniques that leverages endogenous tissue properties to reveal a milieu of deep tissue phenotypes including myocardial inflammation, fibrosis, metabolism, and microstructural defects. Among these phenotypes, myocardial microstructure has proven to be most sensitive to early myocardial tissue damage and is predictive of myocardial regeneration. In this study, the investigators aim to further study the importance of cardiac microstructure revealed by MRI in patient and healthy population and compare this novel technology with conventional clinical biomarkers.

Key facts

Study ID

NCT05654272

Run by

The Cleveland Clinic

People needed

1000

Starts

2022-09-09

Expected to finish

2042-09-09

Last updated by the study team

2026-05-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥ 18 years of age
• Provision of written informed consent
• If not healthy volunteer, must be diagnosed with cardiovascular disease

You may not qualify if…

• Vulnerable populations will be excluded from this study including Prisoners
• Other contraindications to CMR imaging to be determined by standard MRI protocols
• Decisionally impaired (e.g., dementia or cognitive disability)

Where it is running

• Cardiovascular Innovation Research Center — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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