An Observational Study to Assess Change in Disease Activity When Ubrogepant Tablets Are Combined With Atogepant Tablets to Treat Migraine in Adult Participants
Completed
Conditions studied: Migraine
In brief
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will how effective the combination use of ubrogepant and atogepant is in treating adult participants with migraine. Change in migraine activity will be assessed. Urogepant (Ubrelvy) and Atogepant (Qulipta) are approved drugs for treatment of migraine in adults in the US. Approximately 432 adult participants who are prescribed Ubrogepant and atogepant by their doctors will be enrolled in this study in the United States. Participants will receive ubrogepant oral tablets and atogepant oral tablets as prescribed by their physician. Participants will be followed for 30 days. There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.
Key facts
- Study ID
- NCT05653986
- Run by
- AbbVie
- People needed
- 391
- Starts
- 2022-12-18
- Expected to finish
- 2024-08-05
- Last updated by the study team
- 2026-06-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Reports meeting migraine diagnostic criteria consistent with International Classification of Headache Disorders (ICHD) (i.e., they report symptoms accompanying their headaches that meet migraine criteria22 at screening).
- Currently using ubrogepant for acute treatment of migraine.
- Experienced at least 3 migraine attacks in the last 30 days.
- Currently taking atogepant for preventive treatment of migraine and has been taking atogepant, at the same dose, for at least 30 days.
You may not qualify if…
- Report currently taking Rimegepant (Nurtec®) for migraine treatment (acute or preventive).
- Report currently taking any of the anti-CGRP mAbs for preventive treatment of migraine:
- Erenumab (Aimovig®)
- Galcanezumab (Emgality®)
- Fremanezumab (Ajovy®)
- Eptinezumab (Vyepti®)
Where it is running
- Montefiore/Albert Einstein /ID# 252243 — The Bronx, New York, United States
Full record on ClinicalTrials.gov
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