Monitoring and Early Response Evaluation Using HPV DNA - A Study on Patients With HPV-positive Throat Cancer (MER-HPV)

Recruiting now

Conditions studied: Oropharynx Squamous Cell Carcinoma

In brief

The goal of this clinical trial is to determine the value of circulating tumour HPV DNA (human papilloma virus DNA found in the blood) at diagnosis, during treatment, and in the follow-up of patients diagnosed and treated for throat cancer caused by HPV. The main question to answer is if the presence of HPV DNA in the blood one month after the treatment is useful in detecting remaining tumour or relapse within two years after treatment. The participants will be asked to provide blood tests: 1. before treatment 2. weekly during the treatment 3. on all scheduled follow-up appointments 4. on all unplanned appointments where a relapse is suspected

Key facts

Study ID

NCT05649865

Run by

Region Skane

People needed

150

Starts

2023-05-15

Expected to finish

2028-05-01

Last updated by the study team

2023-06-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Only patients with an HPV-positive primary tumour will eventually be eligible for inclusion.
• Non-detectable ctHPVDNA at diagnosis will not be a reason for exclusion.
• Age >18 years.
• Able to give informed consent.
• The patient will be treated with curative intent.

You may not qualify if…

• Patients with a short life expectancy, psychiatric or addictive disorders, or other medical conditions which might impair patient compliance may be excluded at the discretion of the investigator.

Where it is running

• Dept. of ORL-HNS — Lund, Skåne County, Sweden (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.