Emergency Department Triage of Patients With Acute Chest Pain Based on the ESC 0/1-hour Algorithm (PRESC1SE-MI)

Running, not enrolling · Not applicable

Conditions studied: Acute Chest Pain, NSTEMI - Non-ST Segment Elevation MI

In brief

The PRESC1SE-MI study compares two algorithms for triage of patients presenting with chest pain and symptoms of heart attack (myocardial infarction) to the emergency department. Both algorithms are recommended by the European Society of Cardiology: the 0/3-hour algorithm and the 0/1-hour algorithm. Currently, most emergency departments worldwide use the 0/3-hour troponin algorithm. Cardiac troponin (cTn) is a heart-specific biomarker which indicates damage of the heart muscle and which increases after a heart attack. In the 0/3-hour algorithm, the amount of troponin in the bloodstream is measured with a high-sensitivity assay at admission and 3 hours thereafter. Likewise, the 0/1-hour algorithm means that the blood sample in which the troponin is measured is collected at admission and 1 hour later. Since recent clinical studies suggest that the 0/1-hour algorithm is superior to the 0/3-hour algorithm, many hospitals consider switching to the 0/1-hour algorithm. The aim of this study is to assess how feasible the time-saving 0/1-hour algorithm would be in reality and whether it provides the same accuracy and safety in the diagnosis of myocardial infarction as the current practice the 0/3-hour algorithm.

Key facts

Study ID

NCT05649384

Run by

University Hospital, Basel, Switzerland

People needed

64374

Starts

2020-12-01

Expected to finish

2028-05-31

Last updated by the study team

2026-01-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 18 and above
• Presentation with acute non-traumatic acute chest pain to the emergency department
• Suspicion of acute myocardial infarction

You may not qualify if…

• Terminal kidney failure requiring dialysis
• Cardiac arrest
• Cardiogenic shock

Where it is running

• Baylor St. Luke's Medical Center — Houston, Texas, United States
• St Andrew's War Memorial Hospital Brisbane — Brisbane, Australia
• Vienna General Hospital (AKH Wien) — Vienna, Austria
• University Central Hospital Helsinki — Helsinki, Finland
• Attikon General Hospital Athens — Athens, Greece
• Careggi University Hospital Florence — Florence, Italy
• Azienda Ospedaliera San Giovanni Addolorata — Roma, Italy
• Hospital Città della Salute e della Scienza di Torino — Torino, Italy
• Emergency Institute for Cardiovascular Diseases C.C. Iliescu — Bucharest, Romania
• Konkuk University Medical Center — Seoul, South Korea
• Hospital Clinic Barcelona — Barcelona, Spain
• University Hospital October 12 Madrid — Madrid, Spain
• University Hospital Ramon y Cajal — Madrid, Spain
• Hospital Clínico Universitario Valencia — Valencia, Spain
• Kantonsspital Aarau — Aarau, Switzerland
• St. Claraspital — Basel, Switzerland
• Kantonsspital Luzern — Lucerne, Switzerland
• University Hospital Zurich — Zurich, Switzerland
• Royal London Hospital — London, United Kingdom
• Royal Cornwall Hospitals Treliske — Truro, United Kingdom

Full record on ClinicalTrials.gov

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