A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight

Completed · Phase 3 · Has a placebo group

Conditions studied: Obesity, Diabetes Mellitus, Type 2

In brief

This study will look at how much weight participants will lose and how much blood sugar control they achieve from the start to the end of the study. The weight loss in participants taking the investigational high dose of semaglutide will be compared to the weight loss in people taking "dummy" medicine and a lower dose of semaglutide. In addition to taking the medicine, participants will have talks with study staff about healthy food choices and how to be more physically active. Participants will either get semaglutide or "dummy" medicine. Which treatment participants get is decided by chance. Participants are more likely (4 out of 5) to get semaglutide than the "dummy" medicine. The study medicine will be injected briefly, under skin, with a thin needle, typically in the stomach, thighs, or upper arms. After receiving first dose, the dose of semaglutide will be gradually increased until reaching the target dose. The study will last for about 1.5 years

Key facts

Study ID

NCT05649137

Run by

Novo Nordisk A/S

People needed

512

Starts

2023-01-04

Expected to finish

2024-12-13

Last updated by the study team

2026-04-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female.
• Age above or equal to 18 years at the time of signing informed consent.
• BMI greater than or equal to 30.0 kilograms per square meter (kg/m\^2).
• Diagnosed with type 2 diabetes (T2D) greater than or equal to 180 days prior to the day of screening.
• History of at least one self-reported unsuccessful dietary effort to lose body weight.
• HbA1c 7.0-10.0 percent (53-86 millimoles per mole [mmol/mol]) (both inclusive) as measured by central laboratory at screening.

You may not qualify if…

• A self-reported change in body weight greater than 5 kilograms (kg) (11 pounds [lbs]) within 90 days before screening irrespective of medical records.
• Personal or first-degree relative(s) history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma.
• Renal impairment with estimated Glomerular Filtration Rate (eGFR) less than 30 milliliters per minute per 1.73 square meter (30 mL/min/1.73 m\^2) (less than 45 mL/min/1.73 m\^2 in participants treated with Sodium-glucose Cotransporter-2 [SGLT2i]) according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation as defined by Kidney Disease: Improving Global Outcomes (KDIGO) 2012 by the central laboratory at screening.
• Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within 90 days before screening or in the period between screening and randomization. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.

Where it is running

• Chambliss Clinical Trials, LLC — Montgomery, Alabama, United States
• John Muir Physicians Network — Concord, California, United States
• Velocity Clinical Research Westlake — Los Angeles, California, United States
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States
• New West Physicians PC — Golden, Colorado, United States
• ARS- Deland CRU — DeLand, Florida, United States
• Jacksonville Ctr for Clin Res — Jacksonville, Florida, United States
• Florida Inst For Clin Res LLC — Orlando, Florida, United States
• Oviedo Medical Research, LLC — Oviedo, Florida, United States
• Hope Clin Res & Wellness — Conyers, Georgia, United States
• AMC Community Endocrinology — Albany, New York, United States
• University of North Carolina — Chapel Hill, North Carolina, United States
• PharmQuest Life Sciences LLC — Greensboro, North Carolina, United States
• Amarillo Med Spec LLP — Amarillo, Texas, United States
• Elligo Clin Res Centre — Austin, Texas, United States
• Velocity Clin Res, Dallas — Dallas, Texas, United States
• UT Southwestern Medical Center - Lingvay — Dallas, Texas, United States
• PlanIt Research, PLLC — Houston, Texas, United States
• DCOL Ctr for Clin Res — Longview, Texas, United States
• Sugar Lakes Family Practice PA — Sugar Land, Texas, United States
• National Clin Res Inc. — Richmond, Virginia, United States
• Selma Medical Associates — Winchester, Virginia, United States
• MHAT - Blagoevgrad AD, Department of Internal Diseases — Blagoevgrad, Bulgaria
• IPSOMC - Dr. Georgi Marinov — Burgas, Bulgaria
• Univ of Alabama Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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