Parent Study: Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA) Sub-study: Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA Sub-study)

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: COVID-19, SARS-CoV-2

In brief

AZD3152, a single mAb, is being developed to have broad neutralizing activity across known SARS-CoV-2 variants of concern for pre-exposure prophylaxis of COVID-19. The aim of the Phase I/III study (Parent Study) will be to evaluate the safety, efficacy and neutralizing activity of AZD3152 compared with comparator for pre exposure prophylaxis of COVID-19, and separately evaluate the safety and PK of AZD5156, a combination of AZD3152 and AZD1061. Sub-study: This Phase II sub-study of SUPERNOVA will assess the safety, PK, and predicted neutralizing activity of AZD3152 compared with EVUSHELD for pre-exposure prophylaxis of COVID-19.

Key facts

Study ID
NCT05648110
Run by
AstraZeneca
People needed
3882
Starts
2022-12-16
Expected to finish
2025-02-11
Last updated by the study team
2026-06-18

Who can join

Age: 12 and older, up to 130. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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