Extracellular Vesicles and Dysregulated Coagulation in the Prediction of Stroke

Recruiting now

Conditions studied: Stroke, Ischemic, Transient Ischemic Attack, Coagulation Disorder

In brief

Annually 100,000 strokes occur, placing stroke as the largest cause of disability in the UK. 90% of strokes are preventable, leading to national focus on programmes including "The National Stroke Programme" to act on preventing, treating, and improving post-stroke care. Importantly, over 25% of ischaemic stroke sufferers have previously had a Transient Ischaemic Attack (TIA), which presents the biggest concern for TIA patients. There are no measures which reliably identify TIA patients most likely to suffer a stroke. Novel biomarkers for predicting stroke are key to addressing this problem. The PREDICT-EV study aims to screen 300 TIA patients and follow them over 12-months. The investigators will determine if a novel biomarker we've identified to increase thrombotic risk (endothelial derived extracellular vesicles) and the resulting increased prothrombin time is associated with patients at highest risk of stroke.

Key facts

Study ID
NCT05645081
Run by
Cwm Taf University Health Board (NHS)
People needed
360
Starts
2021-10-01
Expected to finish
2027-09-01
Last updated by the study team
2024-08-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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