Life's End Benefits of cannaBidiol and tetrahYdrocannabinol

Running, not enrolling · Phase 2 · Has a placebo group

Conditions studied: Agitation, Dementia

In brief

This is a multicenter randomized double-blind placebo-controlled Phase 2 study of an oral combination of tetrahydrocannabinol (THC) and cannabidiol (CBD) compared to placebo over 12 weeks. This study is designed to test the hypothesis that treatment with an oral combination of THC/CBD will reduce agitation hospice care-eligible patients with agitation and dementia as measured by the Cohen Mansfield Agitation Inventory (CMAI) when compared to placebo at 2 weeks. This study will enroll approximately 120 participants of any gender at least 40 years of age who are hospice care-eligible with agitation and dementia (HAD). Participants will be randomized (50:50) to either active study drug (T2:C100) or placebo. The double-blind period of this study is 12 weeks. A 12 week optional open-label extension will be offered to participants who complete the double-blind period.

Key facts

Study ID

NCT05644262

Run by

University of Southern California

People needed

120

Starts

2023-12-18

Expected to finish

2026-08-01

Last updated by the study team

2026-05-04

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provision of signed and dated informed consent from participant or legally authorized representative.
• Person of any sex/gender 40 years of age or older.
• Ability to take or be administered liquid medication.
• Meets DSM-V criteria for Major Neurocognitive Disorder.
• Current clinically significant agitation as demonstrated by an NPI-agitation subscale of 4 or above at Screening.
• Meets at least one of the following requirements:
• Currently enrolled in out-patient or in-patient hospice care.
• Stage 6d on the Functional Assessment Staging Test (FAST).
• Score of 12 or more according to the Advanced Dementia Prognostic Tool (ADEPT) as implemented by the Mitchell Index.
• Willing to agree not to use cannabinoids in any form (e.g., topically applied, ingested, inhaled, or other form of administration), other than the trial medication, during the first 12 weeks of the study.
• Has a third-party clinician (e.g., hospice, palliative care, PCP) who is responsible for medical management of the participant outside the study.
• In the opinion of the investigator, resides in an environment suitable to conduct a clinical trial (i.e., study intervention can be administered and concomitant medication use can be accurately documented).
• In the opinion of the site PI, has a study partner (may be paid or unpaid caregiver) able and willing to provide accurate information about the participant, oversee the administration of study drug, and participate in study visits and informant-based assessments (usually requires at least 5 hours of contact per week).
• NOTE: Other knowledgeable informants/informed caregivers may contribute to informant-based scales; however, the site should identify an informant who will be able to serve as the primary source of information.
• As assessed by investigator, participant is likely to be able to comply with the protocol for a minimum of 2 weeks.

You may not qualify if…

• Use of cannabinoids or other forms of marijuana in the 3 weeks prior to Baseline, as based on self-report.
• Suspected or known allergic reactions, adverse reactions, or hypersensitivity to cannabinoids and/or components (e.g., (<specify oil to be used in final formulation, e.g.: coconut oil; sesame oil>) of the study drug (T2:C100 or placebo).
• Treatment with another investigational drug or other investigational intervention within the previous 30 days or five half-lives of the investigational product, whichever is longer.
• Any condition, which in the opinion of the site PI, Data and Coordinating Center, regulatory sponsor, or Project Lead/Protocol PI, makes the participant unsuitable for inclusion.

Where it is running

• Georgetown University — Washington D.C., District of Columbia, United States
• Howard University — Washington D.C., District of Columbia, United States
• Melgar-Caro Medcenter and Community Research (MCMCR) — Miami, Florida, United States
• University of South Florida — Tampa, Florida, United States
• University of Kentucky — Lexington, Kentucky, United States
• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States
• University of Maryland — Baltimore, Maryland, United States
• Case Western Reserve University — Beachwood, Ohio, United States
• Ralph H. Johnson VA Medical Center — Charleston, South Carolina, United States
• Vanderbilt University Medical Center Center for Cognitive Medicine — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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