Impact of Dietary Fiber Supplementation on Colonic Microbiome

Recruiting now · Not applicable

Conditions studied: Benign Colorectal Neoplasm, Non-Neoplastic Anal Disorder

In brief

This clinical trial tests whether daily fiber supplementation will change the mucosal microbiome of the colon. The microbiome are microorganisms that live in the human gut. They serve a vital role in maintaining health. Certain microbial strains are associated with the growth of colon polyps, which eventually could go on to form colon cancer. Giving dietary fiber supplements may help prevent precancerous polyps from ever developing.

Key facts

Study ID

NCT05643859

Run by

OHSU Knight Cancer Institute

People needed

120

Starts

2023-04-01

Expected to finish

2026-12-31

Last updated by the study team

2026-01-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >= 18 years
• Ability to understand and the willingness to sign a written informed consent document
• Patients who present with a chief complaint of a benign anorectal pathology including hemorrhoids, anal fissures, and anal fistulas without underlying conditions such as colorectal cancer or Crohn's disease or are undergoing a standard of care colonoscopy procedure

You may not qualify if…

• Patients with an active malignancy, Crohn's disease, ulcerative colitis, and immunosuppressed patients
• Patients with hereditary colon cancer syndrome including Lynch syndrome or Familial Adenomatous Polyposis (FAP)
• Patients with a prior history of total or partial colon resection
• Colorectal pathology, such cancer or proctitis, after initial study scope

Where it is running

• OHSU Knight Cancer Institute — Portland, Oregon, United States (enrolling)

Full record on ClinicalTrials.gov

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