Feasibility of Reducing Respiratory Drive Using the Through-flow System

Recruiting now · Not applicable

Conditions studied: Respiratory Insufficiency, Diaphragm Injury, Lung Injury

In brief

Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury. Mechanical stress and strain applied by mechanical ventilation or by the patient's own respiratory muscles can also cause injury to the lungs. Diaphragm and lung injury are associated with increased morbidity and mortality. Throughflow is a novel system that can reduce dead space without the need to increase the tidal ventilation, reducing the ventilatory demands and respiratory drive.

Key facts

Study ID

NCT05642832

Run by

University Health Network, Toronto

People needed

15

Starts

2024-01-01

Expected to finish

2025-08-31

Last updated by the study team

2024-12-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• PaO2/FiO2 less than or equal to 300 at time of screening
• Oral endotracheal intubation with ETT 7.5 or 8.0 and on invasive mechanical ventilation
• Bilateral airspace opacities on chest radiograph or chest CT scan

You may not qualify if…

• Contraindication to esophageal catheterization (upper gastrointestinal tract surgery within preceding 6 weeks, bleeding esophageal/gastric varices)
• Intubation for traumatic brain injury or stroke
• Intracranial hypertension (suspected or diagnosed by medical team)
• Anticipated liberation from mechanical ventilation within 24 hours

Where it is running

• University Health Network — Toronto, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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