Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma

Recruiting now

Conditions studied: Vestibular Schwannoma, Ototoxicity

In brief

The investigators aim to study the impact of stereotactic radiosurgery, for the treatment of vestibular Schwannoma, on the cochlear, vestibular, gustatory, and facial nerve functions and compare it with a conservatively treated group. The predictive value of radiological tumor characteristics on hearing preservation and vestibular function will be also evaluated. Additionally, the investigators will invite patients with vestibular Schwannoma to fill out questionnaires to assess their quality of life.

Key facts

Study ID

NCT05641441

Run by

University Hospital, Geneva

People needed

258

Starts

2023-01-24

Expected to finish

2030-11-15

Last updated by the study team

2025-01-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18 years or above
• Patients with unilateral VS treated either with SRS or MRI-based observation strategy, as proposed by the institution's skull base tumor board independently of the study
• Patients willing to take part in the study and give their informed consent

You may not qualify if…

• Previous surgical or radiation therapy for VS (including SRS)
• Patients diagnosed with neurofibromatosis type II
• Preexisting profound hearing loss, with a pure tone average (PTA) >90 and word recognition score (WRS) <10%, upon initial assessment
• Previous middle ear surgery of the affected ear
• Concurrent treatment with other experimental drugs

Where it is running

• Service d'ORL et Chirurge cervico-faciale, Hopitaux Universitaires de Genève — Geneva, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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