Vaginal Microbiome and HPV Pre-malignant and Cervical Dysplasia

Recruiting now

Conditions studied: Human Papilloma Virus, Vaginal Flora Imbalance, Cancer Cervix Uterus, Cervical Dysplasia

In brief

In this study, the investigators will prospectively collect, analyze and integrate information regarding vaginal microbiome composition and HPV presence in women with cervical pathologies (high-grade CIN and CC) and controls, to construct a large dataset from patients with pre-cancerous cervical lesions and healthy women, to evaluate the personalized contribution of the vaginal microbiome to the CIN-CC sequence.

Key facts

Study ID

NCT05640700

Run by

Hadassah Medical Organization

People needed

90

Starts

2022-11-09

Expected to finish

2025-12-30

Last updated by the study team

2025-03-19

Who can join

Age: 25 and older, up to 70. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age 25-70
• Attended the clinic for a Pap smear or colposcopy

You may not qualify if…

• Patient does not approve sample collection
• Usage of antibiotics in the month prior to clinic visit
• Usage of any vaginal preparation or medication in the week prior to sample collection (anti-fungal, spermicides, lubricant etc.)
• Menstruation
• Pregnancy

Where it is running

• Hadassah Medical Center — Jerusalem, Israel (enrolling)

Full record on ClinicalTrials.gov

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