Pregabalin Versus Dexmedetomidine for Delirium Treatment After Coronary Artery Bypass Grafting

Recruiting now · Phase 4

Conditions studied: Pregabalin, Delirium Treatment, Coronary Artery Bypass Grafting, Dexmedetomidine

In brief

The aim of this study is to determine the effect of pregabalin versus dexmedetomidine on the treatment and lasting duration of delirium in fast tracking elderly patients after Coronary Artery Bypass Grafting.

Key facts

Study ID

NCT05640453

Run by

Tanta University

People needed

70

Starts

2022-12-15

Expected to finish

2026-05-15

Last updated by the study team

2025-06-25

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• CABG patients ≥ 65 years of age both genders American Society of Anesthesiologists (ASA) physical status classification II or III planned for fast track developed postoperative delirium (POD).

You may not qualify if…

• Patients who had history of psychiatric diseases; inability to communicate;
• previous history of POD; preoperative sick sinus syndrome, allergy/sensitivity to pregabalin or dexmedetomidine, severe bradycardia (heart rate <50 beat per minute), second-degree or above atrioventricular block without pacemaker; severe hepatic or renal insufficiency.
• Previous cardiac or thoracic surgery, known diagnosis of depression or other major psychiatric diseases, cognitive impairment or inability to cooperate with the study, renal insufficiency, and history of substance abuse.

Where it is running

• Islam Morsy — Tanta, El-Gharbia Governorate, Egypt (enrolling)

Full record on ClinicalTrials.gov

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