Multisite Transcranial Direct Current Stimulation to Promote Hand Function Recovery After Stroke
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Stroke
In brief
A novel multisite high definition tDCS (HD-tDCS) in healthy people showed that such network-targeted stimulation could enhance motor excitability beyond traditional stimulation which targeting only one region. It showed that the excitability following multisite HD-tDCS was more than double the increase following conventional tDCS. To consider the various lesion site of different stroke survivors. The electrode placements based on personalized lesion profiles and anatomical features can be determined using finite element modeling, with lesion profiles generated from fMRI and advanced algorithms calculating the current density to maximize the modulation effect. Combining motor network interaction and the new multisite electrode montage may further provide a potential to facilitate stroke recovery.
Key facts
- Study ID
- NCT05638464
- Run by
- Chinese University of Hong Kong
- People needed
- 50
- Starts
- 2021-08-13
- Expected to finish
- 2024-12-01
- Last updated by the study team
- 2024-09-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- first-ever stroke, the duration after stroke exceeds 12 months;
- mild to moderate upper extremity motor function deficit, determined by the Fugl-meyer assessment of upper extremity (FMAUE) scores between 15 and 53;
- detectable voluntary muscle sEMG signal from flexor digitorum (FD) and extensor digitorum (ED);
- scored below 3 in the Modified Ashworh Score (MAS) of FD and ED;
- sufficient cognitive function to follow the assessment and training instructions, determined by Mini Mental State Examination score of more than 21.
You may not qualify if…
- history of epilepsy, or any other contradictions of brain stimulation;
- severe joint contracture of elbow or shoulder, or pain induced by any other neurological, neuromuscular, and orthopedic diseases.
Where it is running
- Department of Biomedical Engineering, The Chinese University of Hong Kong — Hong Kong, Hong Kong (enrolling)
Full record on ClinicalTrials.gov
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