Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients
Recruiting now · Phase 4 · Has a placebo group
Conditions studied: Frailty, Esmolol, Myocardial Injury
In brief
This topic will focus on the following questions: 1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the predictive factors of myocardial injury after non-cardiac surgery （MINS） in elderly frail patients before operation. 2. Part Two: To explore the effect of low-dose esmolol on myocardial injury after non-cardiac surgery in frail elderly patients.
Key facts
- Study ID
- NCT05635877
- Run by
- Yongtao Sun
- People needed
- 2000
- Starts
- 2023-02-07
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2023-03-29
Who can join
Age: 65 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 65 years;
- ASA: ⅰ-ⅳ;
- Modified frailty index (mFI) ≥ 0.21;
- Patients undergoing non-cardiac surgery.
You may not qualify if…
- Refuse to participate;
- Expected hospital stay <3 days;
- Preoperative β-blocker therapy;
- History of myocardial infarction or coronary artery disease;
- Preoperative bradycardia (heart rate [HR] < 50 bpm) or arrhythmia;
- Significant cardiac insufficiency (i.e., pulmonary artery pressure >18 mm Hg, cardiac index ≤ 2.2 L/min/m 2);
- Severe valvular heart disease;
- Severe lung disease (e.g. asthma or chronic obstructive pulmonary disease);
- Patients with perioperative troponin elevation due to nonischemic causes (e.g., sepsis, pulmonary embolism, arrhythmia);
- The same patient can only be included once, regardless of whether the reason for the second operation is related to the first cause.
Where it is running
- Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University — Jinan, Shandong, China (enrolling)
Full record on ClinicalTrials.gov
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