NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI

Starting soon · Phase 2 · Has a placebo group

Conditions studied: Spinal Cord Injuries, Autonomic Dysreflexia

In brief

This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.

Key facts

Study ID

NCT05635851

Run by

Simon Fraser University

People needed

26

Starts

2026-12-01

Expected to finish

2028-02-01

Last updated by the study team

2026-04-23

Who can join

Age: 19 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• participants must have had a traumatic spinal cord injury at least one year ago
• regular bowel care routine
• can communicate in English

You may not qualify if…

• cauda equina or conus lesions
• currently use ventilator
• colostomy, or do not perform regular bowel care
• skin breakdown (pressure sores)
• cannot communicate in English
• under 19 years old
• possibly or certainly pregnant
• medical/psychiatric condition or substance abuse that is likely to affect ability to complete study
• currently using medications containing PDE-5 inhibitors
• currently using medications containing GTN
• allergy to GTN

Full record on ClinicalTrials.gov

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