Postural Sway and Counterpressure Maneuvers for Pediatric Syncope

Recruiting now · Not applicable

Conditions studied: Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance

In brief

The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint. We will record cardiovascular responses to maneuvers of exaggerated sway, leg crossing, crouching, and gluteal muscle tensing in children who faint (N=20), as well as their height, weight, muscularity, and pubertal (Tanner) stage. Autonomic cardiovascular control will be measured using a Valsalva manoeuvre (expiration against a closed airway for 20 seconds) and a supine-stand test. The primary outcomes are noninvasive measures of cardiovascular responses to the maneuvers (blood pressure, cerebral blood flow, and stroke volume (volume of blood pumped per heartbeat). Comparisons will be made across levels of sex, diagnosis, Tanner stage, muscularity, height, and degree of autonomic control.

Key facts

Study ID

NCT05633693

Run by

Simon Fraser University

People needed

30

Starts

2023-04-17

Expected to finish

2027-06-01

Last updated by the study team

2026-04-23

Who can join

Age: 6 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• We are looking for English speaking pediatric patients aged 6-18 years with a diagnosis of recurrent fainting (at least two episodes of fainting with loss of consciousness or near loss of consciousness in the last year) of a vasovagal origin or associated with the postural orthostatic tachycardia syndrome (POTS) (as determined by a paediatric cardiologist) to take part in this study.

You may not qualify if…

• Those with a diagnosis of recurrent fainting accompanied by any of the following will not be eligible to take part:
• Known history of:
• Suspected or confirmed cardiac arrhythmia (e.g., Wolff-Parkinson-White, Long QT)
• Traumatic head injury
• New presentation of a seizure disorder OR epilepsy recurrence
• Overdose or intoxication
• Structural heart disease
• Cardiovascular disease including hypertension, diabetes, or renal disease
• Hypoglycemia
• Physical and/or psychological disability that impact their ability to complete the tests
• Female participants of childbearing age will be excluded if they are pregnant, or think they might be. Participants who are taking any cardiovascular acting medications, including treatment for cardiovascular disease, or medications for orthostatic syncope (e.g. fludrocortisone, slow-release sodium chloride, β-blockers, midodrine) will be excluded from the study.
• In order to reduce the likelihood of transmission of COVID-19, participants will only be eligible to participate in the study if they have received full immunisation against COVID-19 according to current Health Canada guidelines. Accordingly, participants will be asked to provide evidence of their vaccination status in order to take part in the study.

Where it is running

• Simon Fraser University — Burnaby, British Columbia, Canada (enrolling)

Full record on ClinicalTrials.gov

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