Efficacy and Safety Study of Efgartigimod in Adults With Post-COVID-19 POTS

Completed · Phase 2 · Has a placebo group

Conditions studied: Postural Orthostatic Tachycardia Syndrome

In brief

The study aims to investigate the safety, tolerability, efficacy, pharmacodynamics (PD), pharmacokinetics (PK), and immunogenicity of efgartigimod compared to placebo in participants with post-COVID-19 postural orthostatic tachycardia syndrome (POTS) (post-COVID-19 POTS).

Key facts

Study ID

NCT05633407

Run by

argenx

People needed

53

Starts

2022-09-23

Expected to finish

2024-04-18

Last updated by the study team

2025-05-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Reached the age of consent when signing the informed consent form
• Capable of providing signed informed consent and complying with protocol requirements
• Diagnosed with new-onset POTS post-COVID-19 established by the following:
• History of COVID-19 based on a previous positive test result from either laboratory-confirmed COVID-19 test (eg, a PCR test) or non-laboratory-confirmed COVID-19 test (eg, rapid antigen test); this positive result may be either documented or patient-reported
• Tilt table or orthostatic vital sign measurements during screening consistent with consensus criteria: sustained HR increase of ≥30 bpm within 10 min of standing or head up tilt (≥40 bpm for individuals aged 18 to 19 years) and/or HR reaching >120 bpm within 10 min; absence of sustained 20 mmHg decrease in systolic blood pressure (SBP)
• Ongoing symptoms of POTS confirmed by the investigator with at least 3 symptoms in each of the following areas lasting longer than 12 weeks after either diagnosis of COVID-19 or after hospital discharge for COVID-19:
• i. Vasomotor symptoms: fatigue, orthostatic intolerance, brain fog, exertional dyspnea, difficulty with concentration, venous pooling, and exercise intolerance ii. Sympathetic over-compensation symptoms: palpitation, heat intolerance, nausea with or without vomiting, insomnia, anxiety, lack of appetite, chest pain, and diaphoresis
• COMPASS 31 ≥35 at screening
• Agree to use contraceptives consistent with local regulations regarding the methods of contraception for those participating in clinical studies and the following:
• Male participants: No male contraception is required Female participants of childbearing potential must have a negative serum pregnancy test at screening and a negative urine pregnancy test at baseline before receiving IMP. Contraceptive requirements.
• Body mass index (BMI) <35 kg/m2

You may not qualify if…

• Diagnosis of or receiving treatment for the following conditions before COVID-19: peripheral neuropathy, POTS, myalgic encephalomyelitis encephalitis/chronic fatigue syndrome, Ehlers Danlos syndrome confirmed by genetic testing, autonomic neuropathy, multiple sclerosis, stroke, spinal cord injury, or any known lesions in the central nervous system by imaging or neurological exam
• History of or currently being treated for clinically significant ongoing cardiac arrythmia, heart failure, myocarditis, pulmonary embolism requiring anticoagulation, pulmonary fibrosis, or critical illness-related polyneuropathy or myopathy
• Known autoimmune disease that, in the investigator's judgment, would interfere with an accurate assessment of clinical symptoms of post-COVID-19 POTS or puts the participant at undue risk
• Known HIV disease or common variable immunodeficiency
• History of malignancy unless considered cured by adequate treatment with no evidence of recurrence for ≥3 years before the first administration of IMP. Adequately-treated participants with the following cancers may be included at any time:
• Basal cell or squamous cell skin cancer
• Carcinoma in situ of the cervix
• Carcinoma in situ of the breast
• Incidental histological finding of prostate cancer (TNM stage T1a or T1b)
• Clinically significant uncontrolled active or chronic bacterial, viral, or fungal infection or positive SARS-CoV-2 PCR test at screening
• Positive serum test at screening for an active infection with any of the following:
• Hepatitis B virus (HBV) that is indicative of an acute or chronic infection, unless associated with a negative HB surface antigen (HBsAg) or negative HBV DNA test
• Hepatitis C virus (HCV) based on HCV antibody assay unless a negative RNA test is available
• HIV
• A medical condition that could confound the results of the study or put the participant at undue risk in the investigator's judgment
• Clinically significant disease, recent major surgery (within 3 months of screening), or intends to have surgery during the study; or any other condition that in the opinion of the investigator could confound the results of the study or put the participant at undue risk
• Total IgG <4 g/L at screening
• Received within 12 weeks or 5 half-lives (whichever is longer) before screening an investigational product
• Received within 12 weeks before screening either intravenous immunoglobulin (Ig) IV or SC or plasmapheresis/plasma exchange (PLEX)
• Received a live or live-attenuated vaccine less than 4 weeks before screening
• Known hypersensitivity to IMP or 1 of its excipients
• Previously participated in an efgartigimod clinical study and received at least 1 dose of IMP
• Currently participating in another interventional clinical study
• History (within 12 months of screening) of or current alcohol, drug, or medication abuse
• Pregnant or lactating or intends to become pregnant during the study

Where it is running

• University of California, San Diego Sulpizio Cardiovascular Center — La Jolla, California, United States
• Stanford Movement Disorder Center — Palo Alto, California, United States
• Northshore University Health System — Glenview, Illinois, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Harvard Medical School, Brigham and Women's Hospital — Boston, Massachusetts, United States
• Case Western Reserve University — Cleveland, Ohio, United States
• Vandetbilt University Medical Center / Clinical Research Center — Nashville, Tennessee, United States
• Apex Trials Croup, LLC — Fort Worth, Texas, United States
• Texas Institute of Cardiology — McKinney, Texas, United States
• Pioneer Clinical Research — Rosharon, Texas, United States
• Metrodora Institute — West Valley City, Utah, United States

Full record on ClinicalTrials.gov

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