Breathing & Blood Pressure
Recruiting now
Conditions studied: Healthy, Overweight and Obesity
In brief
The purpose of this study is to determine the effect of obesity on cardiovascular responses during various breathing maneuvers.
Key facts
- Study ID
- NCT05632406
- Run by
- Florida State University
- People needed
- 80
- Starts
- 2023-10-25
- Expected to finish
- 2027-06-30
- Last updated by the study team
- 2026-06-26
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Body mass index values of ≤40 kg/m\^2
You may not qualify if…
- Not weight stable (<5% change in body mass over the past six months)
- Overt cardiovascular, neurological, renal, liver, and/or metabolic illness (e.g., diabetes mellitus)
- Current, or history of uncontrolled, Stage 2 hypertension (blood pressure >140 / 90 mmHg; anti-hypertensive medications are permitted)
- Diagnosed obstructive sleep apnea
- Previous bariatric surgery
- Diagnosis or signs (e.g., values below the lower limit of normal) of overt airway disease(s)
- Current or recent (regular use within the past 6 months) use of tobacco or nicotine products (e.g., cigarettes, vaping)
- Per the POWERbreathe® company:
- Patients who have undergone recent abdominal surgery and those with abdominal hernia.
- Asthma patients who have a very low symptom perception and suffer from frequent, severe exacerbations or with an abnormally low perception of dyspnoea.
- If a patient is suffering from a ruptured eardrum or any other condition of the ear.
- Patients with marked elevated left ventricular end-diastolic volume and pressure.
- Patients with worsening heart failure signs and symptoms after a respiratory/inspiratory muscle training (IMT) session
- If you are suffering from a cold, sinusitis, or respiratory tract infection, we advise that you do not use your POWERbreathe IMT device.
- Individuals who are not yet adults (infants, children, teenagers)
- Pregnant (self-reported and urine pregnancy test conducted), lactating (self-reported), or post-menopausal (self-reported) females
- Prisoners
Where it is running
- Florida State University — Tallahassee, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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