Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor

Recruiting now

Conditions studied: Neuromuscular Blockade

In brief

A quantitative neuromuscular monitoring device is desirable to titrate the depth of neuromuscular block (NMB) during a procedure, and to prevent residual effects after removal of the endotracheal tube. Unfortunately, the most widely used monitoring technique acceleromyography (AMG) typically implies a series of cumbersome installation and calibration procedures that frequently precludes correct use of these devices in clinical practice. Electromyography (EMG) has recently attracted a lot of attention as an alternative strategy to compensate for the deficiency of AMG-based neuromuscular monitors. Nowadays, a new technology that allows for the simultaneous acquisition of EMG and AMG signals is commercially available. Although its reliability has been rapidly accepted in Physical Medicine and Rehabilitation, the use of the technique in neuromuscular monitoring has never been reported. The aim of the present study is to assess the validity of the new device for estimating the neuromuscular block by comparing with TOF Watch®-SX, which is the most widely accepted AMG-based neuromuscular monitor that has been practiced in the clinical arena for decades.

Key facts

Study ID

NCT05632107

Run by

Huazhong University of Science and Technology

People needed

100

Starts

2023-03-01

Expected to finish

2027-12-01

Last updated by the study team

2026-04-03

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age less than 18 yr
• American Society of Anesthesiologists Physical Status I to III
• Elective surgery requiring muscle relaxation
• Patients participated voluntarily and signed informed consent

You may not qualify if…

• Patients with known neuromuscular disorder
• Stroke
• Patients with a history of allergic reaction toneuromuscular blocking agents
• Use of medications that might interfere with neuromuscular transmission
• Any previous injury to the examined arm that might influence nerve conduction parameters
• Pacemaker

Where it is running

• Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (enrolling)
• Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (enrolling)

Full record on ClinicalTrials.gov

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