Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

Recruiting now

Conditions studied: Metastatic Prostate Carcinoma, Stage IIIB Prostate Cancer AJCC v8, Stage IIIC Prostate Cancer AJCC v8, Stage IV Prostate Cancer AJCC v8

In brief

This trial evaluates whether a network of peer genetic coaches is useful for addressing disparities in genetic testing and screening among African American men with prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic). While genetic testing has become central to prostate cancer care, African American men are less likely seek testing due to lack of awareness, cultural beliefs, financial limitations, fear of discrimination, and mistrust in the healthcare system. A network of peer genetic coaches may help address barriers, beliefs, and needs of African American men in the community and provide navigation to increase engagement in genetic testing.

Key facts

Study ID

NCT05627219

Run by

Thomas Jefferson University

People needed

30

Starts

2024-06-03

Expected to finish

2026-09-30

Last updated by the study team

2026-05-15

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• AIM 1: Are 18 years old or older
• AIM 1: Are able to read and speak English comfortably
• AIM 1: Men who have experience with both prostate cancer (PCA) and genetic counseling and testing will be a priority for training, as well as men who have considerable peer education or navigation experience
• AIM 2: Are 18 years old or older
• AIM 2: Are African American
• AIM 2: Are able to read and speak English comfortably
• AIM 2: Men who meet any one of the following criteria: (1) metastatic prostate cancer; (2) prostate cancer with high-risk features (T3 or higher, Gleason 8 or higher, node positive disease); (3) with or without a diagnosis of prostate cancer with strong family history (2 or more first-degree or second-degree relatives) with prostate cancer (particularly metastatic prostate cancer or died from prostate cancer), breast cancer, ovarian cancer, pancreatic cancer, colorectal cancer, uterine cancer, renal cancer, urothelial cancer, or upper bowel cancer

You may not qualify if…

• Patients that do not meet the inclusion criteria
• Children under the age of 18
• Anyone who has trouble understanding the consent or with significant anxiety detected during the consent process

Where it is running

• Sidney Kimmel Cancer Center at Thomas Jefferson University — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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