Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis
Recruiting now · Phase 4
Conditions studied: Chronic Rhinitis
In brief
The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients. The main question it aims to answer is: Do high volume, high pressure delivery mechanisms in nasal irrigation improve the efficacy of azelastine combined with nasal steroid mometasone as compared to the standard low pressure, low volume delivery mechanisms in nasal sprays? Subjects will complete six months of one of three medication regimens: 1. Saline irrigation followed by azelastine spray and mometasone spray 2. Mometasone saline irrigation 3. Azelastine saline irrigation combined with mometasone saline irrigation.
Key facts
- Study ID
- NCT05626621
- Run by
- Endeavor Health
- People needed
- 81
- Starts
- 2022-11-23
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2023-07-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults 18 years and older seeking treatment for chronic rhinitis and willing to undergo six months of topical therapy.
- Diagnosis of Chronic Rhinitis.
You may not qualify if…
- The patient has diagnosis(es) other than chronic rhinitis that can account for his/her symptoms (septal deviation, nasal valve collapse, chronic sinusitis).
- Use of oral antihistamines or oral steroids, unless patient undergoes a 4 week washout period.
- Smokers (tobacco, marijuana, vaping, etc.).
- Known or suspected pregnancy, or lactation.
- Other medical conditions that the investigator believed would confound the study.
- Allergy to study drugs.
Where it is running
- Northshore University HealthSystem — Evanston, Illinois, United States (enrolling)
Full record on ClinicalTrials.gov
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