Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes After Assisted Reproductive Technology

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: ART, Pre-Eclampsia

In brief

This study seeks to validate the hypothesis that nulliparous pregnant women after Assisted Reproductive Technology (ART) are at high risk of preeclampsia and perinatal complications and represent a subgroup for which aspirin prophylaxis during pregnancy may be effective in the prevention of preterm preeclampsia and other perinatal adverse outcomes.

Key facts

Study ID

NCT05625724

Run by

University Hospital, Toulouse

People needed

1164

Starts

2023-08-02

Expected to finish

2029-05-01

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Nulliparous women aged 18 years or more
• Pregnancy following ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), oocyte donation or intrauterine insemination with sperm donor
• Singleton pregnancy
• Evolutive pregnancy between 9 and 14 weeks of gestation
• Women affiliated to a French Social Security Insurance or equivalent social protection
• Written informed consent

You may not qualify if…

• Major fetal abnormality
• Regular treatment with aspirin (including antiphospholipid syndrome)
• Aspirin contraindications (allergy, von Willebrand disease, peptic ulceration, hemophilia)
• Women protected by law.
• Women included in another interventional study.

Where it is running

• CHU Toulouse — Toulouse, France (enrolling)
• CHU Bordeaux — Bordeaux, France (enrolling)
• CHU Clermont-Ferrand — Clermont-Ferrand, France (enrolling)
• CHU Dijon-Bourgogne — Dijon, France (enrolling)
• CHU Lille — Lille, France (enrolling)
• HCL - Groupement Hospitalier Est, Hôpital Femme Mère Enfant — Lyon, France (enrolling)
• AP-HM Hôpital de la Conception — Marseille, France (enrolling)
• AP-HM Hôpital Nord — Marseille, France (enrolling)
• CHU Montpellier — Montpellier, France (enrolling)
• CHRU Nancy — Nancy, France (enrolling)
• CHU Nantes — Nantes, France (enrolling)
• CHU Nîmes — Nîmes, France (enrolling)
• Groupe hospitalier St Joseph — Paris, France (enrolling)
• CHU Strasbourg — Strasbourg, France (enrolling)
• CHU Angers — Angers, France (enrolling)
• Hôpital Cochin — Paris, France (enrolling)
• CHI Poissy Saint Germain en Laye — Poissy, France (enrolling)
• CHU Rennes — Rennes, France (enrolling)
• CHU Saint Etienne, Hôpital Nord — Saint-Etienne, France (enrolling)
• Hôpital Armand - Trousseau — Paris, France
• CHU Poitiers — Poitiers, France

Full record on ClinicalTrials.gov

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