Wayfinding Intervention and Long-Term Memory

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Long-Term Memory Decline, Mild Cognitive Impairment

In brief

Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment. Cognitive training with an immersive video game promises to drive hippocampal-cortical plasticity and associated gains that can restore memory capability or provide therapeutic treatment for memory deficits.

Key facts

Study ID

NCT05625425

Run by

University of California, San Francisco

People needed

200

Starts

2024-01-01

Expected to finish

2027-01-31

Last updated by the study team

2026-05-07

Who can join

Age: 60 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• fluent speakers of English
• completed 12 or more years of education
• normal or corrected-to-normal vision
• dexterity to comfortably operate the scanner-compatible response box
• freedom from physical and neurological conditions contra-indicated for fMRI
• must confirm physical stamina and comfort for semi-weekly brisk 30-minute walks on level ground

You may not qualify if…

• use of psychotropic medications
• history of concussions or dizziness, vestibular or balance problems
• significant discomfort with virtual reality experiences

Where it is running

• UCSF Mission Bay — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

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