High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans

Recruiting now · Not applicable

Conditions studied: Frailty

In brief

Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems. Frailty leads to poorer physical performance and functional capacity and higher risk of adverse outcomes including falls, hospitalization, and mortality. Resilience, defined as the capacity to recover from disruptions to homeostasis, is critical to successful aging because it precedes frailty and enhances adults' ability to maintain optimal health and function well into older age. Evidence- based therapies to help older adults enhance resilience are limited and the biological underpinnings contributing to improved resilience have not yet been fully characterized. To address this important need, the investigators will conduct a clinical trial to examine the benefits of center- and home-based high intensity interval training (HIIT) on functional capacity, frailty, and resilience, and also to identify novel biomarkers of resilience in older Veterans.

Key facts

Study ID

NCT05625204

Run by

VA Office of Research and Development

People needed

200

Starts

2024-01-29

Expected to finish

2027-09-30

Last updated by the study team

2025-12-12

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 65 years and older
• Male and female, any race
• Medically cleared for exercise
• Non-frail or pre-frail (frailty score < 3)
• Ability to use a recumbent exercise bike

You may not qualify if…

• Severe co-morbidity: COPD (GOLD stage IV), CKD ( stage 3)), severe HTN (180 mmHg/120 mmHg)
• VA-SLUMS score 20 or lower (Cognition)

Where it is running

• Kansas City VA Medical Center, Kansas City, MO — Kansas City, Missouri, United States (enrolling)
• Kansas City VA Medical Center, Kansas City, MO — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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