Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Treatment Resistant Depression

In brief

Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)

Key facts

Study ID

NCT05624268

Run by

COMPASS Pathways

People needed

255

Starts

2023-01-19

Expected to finish

2026-04-01

Last updated by the study team

2025-12-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of Arizona College of Medicine - Tuscon — Tucson, Arizona, United States
• ProScience Research Group — Culver City, California, United States
• Collaborative Neuroscience Network, LLC — Garden Grove, California, United States
• Kadima Neuropsychiatry Institute — La Jolla, California, United States
• University California San Diego — La Jolla, California, United States
• California Center for Psychedelic Therapy — Los Angeles, California, United States
• CalNeuro Research Group, Inc — Los Angeles, California, United States
• Clarity Clinical Research, LLC — Los Angeles, California, United States
• ATP Clinical Research, Inc. — Orange, California, United States
• Artemis Institute for Clinical Research — San Diego, California, United States
• Lumos Clinical Research Center — San Jose, California, United States
• Stanford University — Stanford, California, United States
• ASCLEPES Research Centers — Thousand Oaks, California, United States
• Comprehensive Psychiatric Care — Norwich, Connecticut, United States
• Clinical Neurosciecne Solutions, Inc. dba CNS Healthcare — Orlando, Florida, United States
• APG Research, LLC — Orlando, Florida, United States
• DMI Health Care Group, Inc — Tampa, Florida, United States
• Meridien Research/Accel Research — Tampa, Florida, United States
• Psych Atlanta — Atlanta, Georgia, United States
• Emory University — Atlanta, Georgia, United States
• Uptown Research Institute, LLC — Chicago, Illinois, United States
• Sheppard Pratt Health System — Baltimore, Maryland, United States
• CBH Health, LLC — Gaithersburg, Maryland, United States
• Pharmasite Research, Inc — Pikesville, Maryland, United States
• University of Massachusetts Medical School — North Worcester, Massachusetts, United States

Full record on ClinicalTrials.gov

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