Vaccine Immune Recovery After Leukemia
Completed
Conditions studied: Acute Lymphoblastic Leukemia, Pediatric
In brief
This observational study aims to assess recovery of the immune system and immunity to vaccine-preventable diseases in children, adolescents, and young adults who recently completed treatment for acute lymphoblastic leukemia (ALL). Several children's hospitals in the United States are participating in the study, which will enroll up to 100 pediatric participants. The study is intended to determine the rate of infection after leukemia treatment and to inform future studies and recommendations about whether children and adolescents who have leukemia should receive additional vaccine doses or boosters after treatment.
Key facts
- Study ID
- NCT05622682
- Run by
- Children's Hospital of Philadelphia
- People needed
- 89
- Starts
- 2022-09-28
- Expected to finish
- 2025-11-30
- Last updated by the study team
- 2026-01-26
Who can join
Age: 3 and older, up to 31. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Children, adolescents, and young adults diagnosed with B or T ALL at age 12 months or older
- Completed ALL chemotherapy within the past three months or will complete ALL chemotherapy in the upcoming three months
- Three years of age or older at time of enrollment
You may not qualify if…
- Diagnosis of infant ALL
- Evidence of disease relapse
- History of primary immunodeficiency (except related to Down Syndrome)
- History of a stem cell transplant or cellular immunotherapy
- History of prior malignancy or condition requiring chemotherapy other than for current ALL diagnosis
Where it is running
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- Helen DeVos Children's Hospital — Grand Rapids, Michigan, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Monroe Carell Jr. Children's Hospital at Vanderbilt — Nashville, Tennessee, United States
- CHRISTUS Children's (Affiliate of Baylor College of Medicine) — San Antonio, Texas, United States
- Seattle Children's Hospital — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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