A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 in Participants With Diabetic Peripheral Neuropathic Pain (NP05).

Completed · Phase 2 · Has a placebo group

Conditions studied: Diabetic Peripheral Neuropathic Pain

In brief

This study is being done to test the safety and efficacy of the study drug LY3857210 for the treatment of diabetic peripheral neuropathic pain. This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292) which is a protocol to accelerate the development of new treatments for chronic pain.

Key facts

Study ID

NCT05620576

Run by

Eli Lilly and Company

People needed

131

Starts

2022-11-14

Expected to finish

2023-08-01

Last updated by the study team

2024-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a visual analog scale (VAS) pain value greater than or equal to (≥) 40 and less than (<) 95 during screening.
• Have a history of daily pain for at least 12 weeks based on participant report or medical history.
• Have a body mass index <40 kilograms per meter squared (kg/m²) (inclusive).
• Are willing to maintain a consistent regimen of any ongoing nonpharmacologic pain-relieving therapies (for example, physical therapy) and will not start any new nonpharmacologic pain-relieving therapies during study participation.
• Are willing to discontinue all pain medications taken for chronic pain conditions for the duration of the study.
• Have daily symmetrical foot pain secondary to peripheral neuropathy present for at least 6 months and as diagnosed through use of the Michigan Neuropathy Screening Instrument Part B ≥3 (©University of Michigan).
• Have a history and current diagnosis of type 1 or type 2 diabetes mellitus.
• Have stable glycemic control as indicated by a glycated hemoglobin less than or equal to (≤) 11 at time of screening.
• Are men, or women able to abide by reproductive and contraceptive requirements.

You may not qualify if…

• Have had a procedure within the past 6 months intended to produce permanent sensory loss in the target area of interest (for example, ablation techniques).
• Have surgery planned during the study for any reason, related or not to the disease state under evaluation.
• Have, in the judgment of the investigator, an acute, serious, or unstable medical condition or a history or presence of any other medical illness that would preclude study participation.
• Have substance use disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders (5th edition; DSM-5; American Psychiatric Association).
• Have had cancer within 2 years of baseline, except for cutaneous basal cell or squamous cell carcinoma resolved by excision.
• Have fibromyalgia.
• Are, in the judgment of the investigator, actively suicidal and therefore deemed to be at significant risk for suicide.
• Have a positive human immunodeficiency virus (HIV) test result at screening.
• Have an intolerance to acetaminophen or paracetamol or any of its excipients.
• Have a history of alcohol, illicit drug, analgesic or narcotic use disorder within 2 years prior to screening.
• Have a current drug-induced neuropathy, for example, due to some types of chemotherapy, or other types of peripheral neuropathy.
• Have known hereditary motor, sensory or autonomic neuropathies.
• Have a seizure disorder, history of seizure (other than remote history of childhood febrile seizure), or a condition that would place the participant at increased risk of seizure, such as head injury (for example, skull fracture, cerebral contusion, concussion, or trauma resulting in prolonged. unconsciousness), intracranial neoplasm or hemorrhage.
• Are pregnant or breastfeeding.
• Have known or history of gastric or duodenal ulcers.
• Have known or history of inflammatory bowel disease (including ulcerative colitis or Crohn's disease).

Where it is running

• Synexus Clinical Research US, Inc. — Chandler, Arizona, United States
• Arizona Research Center — Phoenix, Arizona, United States
• Artemis Institute for Clinical Research — Riverside, California, United States
• Artemis Institute for Clinical Research — San Diego, California, United States
• CMR of Greater New Haven, LLC — Hamden, Connecticut, United States
• Accel Research Sites- Clinical Research Unit — DeLand, Florida, United States
• Suncoast Research Group — Miami, Florida, United States
• University of Miami Don Suffer Clinical Research Building — Miami, Florida, United States
• New Horizon Research Center — Miami, Florida, United States
• Renstar Medical Research — Ocala, Florida, United States
• Synexus Clinical Research US, Inc - Orlando — Orlando, Florida, United States
• Synexus Clinical Research US, Inc. — Pinellas Park, Florida, United States
• North Georgia Clinical Research — Woodstock, Georgia, United States
• Rocky Mountain Clinical Research — Idaho Falls, Idaho, United States
• Northwestern University — Chicago, Illinois, United States
• Boston Clinical Trials — Boston, Massachusetts, United States
• ActivMed Practices and Research — Methuen, Massachusetts, United States
• MedVadis Research Corporation — Waltham, Massachusetts, United States
• Great Lakes Research Group, Inc. — Bay City, Michigan, United States
• StudyMetrix Research — City of Saint Peters, Missouri, United States
• Clinvest Headlands Llc — Springfield, Missouri, United States
• Lillestol Research — Fargo, North Dakota, United States
• META Medical Research Institute — Dayton, Ohio, United States
• Altoona center for clinical research — Duncansville, Pennsylvania, United States
• FutureSearch Trials of Neurology — Austin, Texas, United States

Full record on ClinicalTrials.gov

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