Feasibility of Egg-Based Diet Interventions and Assessing Perinatal Mental Health

Completed · Not applicable

Conditions studied: Depression, Anxiety, Stress

In brief

The goals of this study are to assess the feasibility and acceptability of a dietary intervention to increase choline intake through whole foods (eggs) in pregnant and lactating women for mental health benefits. We will achieve these goals through the following specific aims: 1. To determine the effects of including eggs as a source of choline in the diets of pregnant and lactating women on biomarkers, we will measure concentrations of choline and choline metabolites in maternal serum and breastmilk at 24-26 weeks gestation and 4-6 weeks postpartum. 2. To evaluate adherence to a food-based dietary choline intervention in pregnant and lactating women, we will track intake via daily photo and written food logs. 3. To assess the feasibility of collecting repeated measures of dietary intake and maternal depression, anxiety, and stress in the perinatal period, we will track completion rates for project surveys. The data from this study will inform the design and sample size calculations for a longitudinal cohort study that will assess neurological outcomes for both mother and child and follow the offspring over time to reassess mental health and cognitive development in preschool-aged children. Choline is an underconsumed nutrient of concern for public health, specifically during pregnancy and lactation. There is limited data on biomarker or health outcomes related to perinatal choline intake. Determining relationships between perinatal choline intake and maternal mental health has the potential to impact public health by ultimately informing development of nutrition education materials in the clinical setting focused on encouraging maternal perinatal choline intake through whole foods such as eggs.

Key facts

Study ID

NCT05619445

Run by

University of Idaho

People needed

1

Starts

2023-06-09

Expected to finish

2023-10-20

Last updated by the study team

2024-12-06

Who can join

Age: 19 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• 18 to 26 weeks pregnant
• have access to internet and an electronic device (phone, tablet, or computer)
• willing to consume eggs

You may not qualify if…

• score 11 or higher on the Edinburgh Postnatal Depression Scale
• under 19 years of age
• non-English speaking
• pregnant with multiples
• consume a vegan diet
• self-reported use of alcohol or drugs during pregnancy
• have diagnosed egg allergy
• have physical, cognitive, or logistical limitations to being able to follow the study protocol
• do not plan to breastfeed

Where it is running

• University of Idaho — Moscow, Idaho, United States

Full record on ClinicalTrials.gov

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