Mindfulness-Based fMRI Neurofeedback for Depression
Recruiting now · Not applicable
Conditions studied: Depression in Adolescence, Rumination
In brief
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.
Key facts
- Study ID
- NCT05617495
- Run by
- Columbia University
- People needed
- 90
- Starts
- 2024-04-10
- Expected to finish
- 2027-06-30
- Last updated by the study team
- 2026-04-29
Who can join
Age: 13 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ages 13-18 years-old
- Written informed assent/consent and parental/guardian permission for 13-17 year-olds or informed consent for 18 year-olds
- Tanner puberty stage ≥3
- Meets current diagnostic criteria for MDD
- English fluency
You may not qualify if…
- Lifetime history of primary psychotic disorders, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or eating disorders
- Substance use disorder, moderate or severe in past 6 months
- Active suicidal ideation with a specific plan
- History of seizure disorder
- Medical or neurological illness (e.g., severe head injury)
- MRI contraindications
- Current psychotropic medication use other than antidepressant medication
- Intelligence quotient (IQ) <80.
Where it is running
- Northeastern University — Boston, Massachusetts, United States (enrolling)
- Columbia University Irving Medical Center — New York, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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