Alzheimer's Disease Neuroimaging Initiative 4

Enrolling by invitation

Conditions studied: Mild Cognitive Impairment, Alzheimer Disease, Dementia

In brief

The Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4) is a non-randomized, longitudinal, natural history study designed to validate biomarkers, improve clinical trial design, and advance understanding of Alzheimer's disease across the full disease spectrum. Building on the success of ADNI1, ADNI-GO, ADNI2, and ADNI3, ADNI4 integrates clinical, cognitive, imaging, genetic, and fluid biomarker data to characterize disease progression and predict cognitive decline. ADNI4 includes both in-clinic and remote cohorts and a small complementary sub-cohort, Together Exploring Aging Minds (TEAM-ADNI), which evaluates community-based recruitment and longitudinal data collection approaches.

Key facts

Study ID

NCT05617014

Run by

University of Southern California

People needed

1500

Starts

2023-06-09

Expected to finish

2027-07-31

Last updated by the study team

2026-07-06

Who can join

Age: 55 and older, up to 90. Sex: any. Healthy volunteers: accepted.

Where it is running

• Banner Alzheimer's Institute — Phoenix, Arizona, United States
• Barrow Neurological Institute — Phoenix, Arizona, United States
• Banner Sun Health Research Institute — Sun City, Arizona, United States
• University of California, Irvine — Irvine, California, United States
• University of California, San Diego — La Jolla, California, United States
• University of California, Los Angeles — Los Angeles, California, United States
• University of Southern California — Los Angeles, California, United States
• Stanford University — Palo Alto, California, United States
• University of California, San Francisco — San Francisco, California, United States
• University of California, Davis — Walnut Creek, California, United States
• Yale University — New Haven, Connecticut, United States
• Georgetown University — Washington D.C., District of Columbia, United States
• Howard University — Washington D.C., District of Columbia, United States
• Mayo Clinic, Jacksonville — Jacksonville, Florida, United States
• Gonzalez MD & Aswad MD Health Services — Miami, Florida, United States
• Wien Center — Miami Beach, Florida, United States
• Charter Research — Orlando, Florida, United States
• University of South Florida Health Byrd Alzheimer's Institute — Tampa, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Northwestern University — Chicago, Illinois, United States
• Rush University Memory Clinic — Chicago, Illinois, United States
• University of Chicago — Chicago, Illinois, United States
• Indiana University — Indianapolis, Indiana, United States
• University of Iowa — Iowa City, Iowa, United States
• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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