Bundled Hyperpolypharmacy Deprescribing
Completed · Not applicable
Conditions studied: Polypharmacy
In brief
Older patients using many prescription drugs (hyperpolypharmacy) may be at increased risk of adverse drug effects. This randomized controlled trial tested the effectiveness and safety of a quality intervention intended to reduce hyperpolypharmacy. The study was set at Kaiser Permanente Northern California, an integrated health system with multiple pre-existing deprescribing workflows. Eligible patients were aged ≥76 years using ≥10 prescription medications. The intervention included physician-pharmacist collaborative drug therapy management, standard-of-care practice recommendations, shared decision-making, and deprescribing protocols administered by telephone over multiple cycles for a maximum of 180 days after allocation. A priori primary effectiveness endpoints included change in the number of medications and in the prevalence of geriatric syndrome from 181-365 days after allocation. Second endpoints included utilization and adverse drug withdrawal effects. Information was obtained from the electronic health record.
Key facts
- Study ID
- NCT05616689
- Run by
- Kaiser Permanente
- People needed
- 2471
- Starts
- 2020-10-19
- Expected to finish
- 2023-05-24
- Last updated by the study team
- 2023-12-15
Who can join
Age: 76 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Kaiser Permanente patients
- Age ≥76 years
- ≥10 drugs (excluding topicals) where
- drug filled ≥2 times in the past year and
- drug last filled < 180 days ago
You may not qualify if…
- less than 12 months preceding enrollment at Kaiser Permanente
- no primary care practitioner assigned
- on dialysis
- history of heart, liver, lung, breast, or bone marrow transplant
- in hospice
- under active treatment for cancer during the past 12 months
- has received an intervention through the Pharmacy Targeted Deprescribing Program in the preceding year.
Where it is running
- Kaiser Permanente Division of Research — Oakland, California, United States
Full record on ClinicalTrials.gov
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