Personalized B-fructan Diet in Inflammatory Bowel Disease Patients

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Inflammatory Bowel Diseases, Ulcerative Colitis

In brief

This study aims to examine patient tolerability of personalized dietary fibre consumption recommendations (high-pectin diet versus high-B-fructan diet based on personalized responses), provided by an IBD dietician, based on our novel translational research findings.

Key facts

Study ID

NCT05615779

Run by

University of Manitoba

People needed

600

Starts

2023-08-01

Expected to finish

2025-12-01

Last updated by the study team

2025-04-06

Who can join

Age: 6 and older, up to 39. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Children (age 6-17) or young adults (age 18-39).
• Known or suspected UC or IBDU [there will be 2 control group: non-IBD (undergoing colonoscopy but found not to have IBD; and healthy (no GI symptoms, so not required to have colonoscopy; could be family members)]
• For UC: Remission-mild-moderate disease: Mayo score <10
• Clinical indication for sedated colonoscopy
• Disease location: E2-E4
• Stable treatment (not on steroids; biologics or immunomodulator not changed in last month)
• High likelihood that patients will be able to collect all samples and provide all data

You may not qualify if…

• Use of antibiotics for a week or more over the last 3 months
• Use of probiotics or prebiotics at pharmacological doses (adding fibre sources to food or probiotics in yogurt, for example, are allowed)
• History of abdominal surgery, including appendectomy
• Documented enteric infection during the 3 months prior to endoscopy
• Presence of non-IBD bowel conditions (e.g., celiac), anatomical or mucosal abnormalities, motility disorder
• Presence of a systemic disease requiring treatment (cancer, ischemic heart disease, kidney failure, etc)
• Proctitis (E1)
• Systemic steroids (above 10 mg/day of Prednisone)
• Topical therapy within 1 week of endoscopy
• Recent change in IBD treatment (started biologics or IM over the last month)
• Pregnancy or planning to become pregnant during the study
• Inability to understand or sign the consent

Where it is running

• University of Alberta Hospital — Edmonton, Alberta, Canada (enrolling)
• Health Sciences Centre Hospital — Winnipeg, Manitoba, Canada (enrolling)

Full record on ClinicalTrials.gov

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