Prospective Evaluation of Neurocognition in Patients Undergoing Transcatheter Aortic Valve Replacement

Completed

Conditions studied: Mild Cognitive Impairment, Aortic Stenosis

In brief

This trail is for patients with mild cognitive impairment (MCI) who are receiving a transcatheter aortic valve replacement (TAVR). We will assess changes in neurocognition following TAVR with the 5 minute Montreal Cognitive Assessment (mini MoCA) when comparing pre procedure with post procedure assessments.

Key facts

Study ID

NCT05614986

Run by

Baylor Research Institute

People needed

81

Starts

2022-01-17

Expected to finish

2024-02-27

Last updated by the study team

2026-01-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Undergoing a TAVR procedure
• Possible MCI as determined by procedures already used in the TAVR clinics, including 1 of the 4:
• MMSE < 27
• History of MCI, dementia, or stroke (CVA or TIA)
• History of prescription treatment for MCI
• Discretion of the investigator, physician, or clinic staff
• Scores 25 or less on the mini MoCA exam

You may not qualify if…

• In another research study that doesn't allow dual enrolment, or dual enrolment has not been granted.

Where it is running

• Baylor Heart and Vascular Hospital — Dallas, Texas, United States
• Baylor Scott & White All Saints at Fort Worth — Fort Worth, Texas, United States
• Baylor Scott and White The Heart Hospital Baylor Plano — Plano, Texas, United States
• Baylor Scott & White Medical Center - Temple — Temple, Texas, United States

Full record on ClinicalTrials.gov

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