Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
Running, not enrolling · Phase 3 · Has a placebo group
Conditions studied: Endometrial Cancer
In brief
The purpose of this study is to evaluate the efficacy and safety of selinexor as a maintenance treatment in patients with p53 wt endometrial carcinoma (EC), who have achieved a partial response (PR) or complete response (CR) (per Response Evaluation Criteria in Solid Tumors version 1.1 \[RECIST v 1.1\]) after completing at least 12 weeks of platinum-based therapy. A total of 276 participants will be enrolled in the study and randomized in a 1:1 ratio to maintenance therapy with either selinexor or placebo.
Key facts
- Study ID
- NCT05611931
- Run by
- Karyopharm Therapeutics Inc
- People needed
- 257
- Starts
- 2023-04-18
- Expected to finish
- 2028-01-01
- Last updated by the study team
- 2026-05-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cork University Hospital — Cork, Ireland
- The University of Alabama at Birmingham — Birmingham, Alabama, United States
- Honor Health — Phoenix, Arizona, United States
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- UC DAVIS — Davis, California, United States
- City of Hope National Medical Center — Duarte, California, United States
- City of Hope at Irvine Lennar — Irvine, California, United States
- Cancer and Blood Specialty Clinic — Los Alamitos, California, United States
- UCLA - Women's Health Clinical Research Unit — Los Angeles, California, United States
- Long Beach Memorial Medical Center — Los Angeles, California, United States
- Stanford University — Palo Alto, California, United States
- California Pacific Medical Center — San Francisco, California, United States
- Broward Health Medical Center — Fort Lauderdale, Florida, United States
- Mount Sinai Comprehensive Cancer Center — Miami Beach, Florida, United States
- Advent Health — Orlando, Florida, United States
- Grady Hospital — Atlanta, Georgia, United States
- Emory University — Atlanta, Georgia, United States
- Georgia Cancer Center at Augusta University — Augusta, Georgia, United States
- Northeast Georgia Medical Center — Gainesville, Georgia, United States
- Illinois Cancer Specialists — Arlington Heights, Illinois, United States
- NorthShore University Health System — Evanston, Illinois, United States
- Northwest Cancer Center — Dyer, Indiana, United States
- Goshen Health — Goshen, Indiana, United States
- St. James Hospital — Dublin, Ireland
- Mackay Memorial Hospital — Taipei, Taiwan
Full record on ClinicalTrials.gov
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