REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study

Running, not enrolling

Conditions studied: Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage, ICH, Hemorrhage, Stroke, Clot (Blood); Brain, Clot Blood, Cognitive Decline, Cognitive Impairment, Survivorship, Memory Impairment, Motor Activity

In brief

The investigators propose to perform serial detailed cognitive, motor, behavioral, and blood collection follow-up using longitudinal structured telephone interviews of an anticipated 350 ICH survivors enrolled in Minimally Invasive Surgery Plus Alteplase for Intracerebral Hemorrhage Evacuation (MISTIE) III and ENRICH trials to identify specific cognitive and motor impairment and to perform RNA sequencing to evaluate for evidence of chronic inflammation. The investigators' expected sample size in 2022 accounts for mortality attrition of 10%/year.

Key facts

Study ID

NCT05611918

Run by

Johns Hopkins University

People needed

350

Starts

2023-05-23

Expected to finish

2027-12-31

Last updated by the study team

2026-06-12

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants in the study must be survivors enrolled in MISTIE III and ENRICH trials at end of each trial's final follow-up (day 365 in MISTIE III and day 180 in ENRICH). Relatives of known survivors that are found to be deceased since the end of each trial will be interviewed to capture relevant data.

You may not qualify if…

• None

Where it is running

• University of Alabama at Brimingham — Birmingham, Alabama, United States
• Scripps Health — La Jolla, California, United States
• Dignity Health component - St. Joseph's Hospital and Medical Center — Sacramento, California, United States
• Stanford University — Stanford, California, United States
• Yale University — New Haven, Connecticut, United States
• Mayo Clinic, Jacksonville — Jacksonville, Florida, United States
• CommonSpirit (formerly Mercy San Juan Medical Center; dignity health) — Chicago, Illinois, United States
• University of Illinois at Chicago — Chicago, Illinois, United States
• University of Kansas Medical Center — Fairway, Kansas, United States
• University of Louisville — Louisville, Kentucky, United States
• University of Maryland Baltimore — Baltimore, Maryland, United States
• Johns Hopkins Hospital — Baltimore, Maryland, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Henry Ford Health System — Detroit, Michigan, United States
• Hennepin Healthcare Research Institute — Minneapolis, Minnesota, United States
• Washington University in St. Louis, School of Medicine — St Louis, Missouri, United States
• Rutgers - Robert Wood Johnson Medical School — Piscataway, New Jersey, United States
• University of New Mexico — Albuquerque, New Mexico, United States
• Albert Einstein Montefiore — The Bronx, New York, United States
• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Thomas Jefferson University — Philadelphia, Pennsylvania, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• University of Texas, Houston Health Science Center — Houston, Texas, United States
• University of Texas Health Science Center at San Antonio — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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