Duloxetine Impact on Postoperative Pain Control and Outcomes

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use, Opioid Addiction

In brief

1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative pain, function, and quality of life. 3. Evaluate the correlation between preoperative screening tests (measuring pain centralization, anxiety, depression, and overall function) and patients' response to treatment (reduction in pain, anxiety, or depression and improvement in function).

Key facts

Study ID

NCT05611749

Run by

Scripps Health

People needed

17

Starts

2023-05-30

Expected to finish

2024-03-25

Last updated by the study team

2025-05-04

Who can join

Age: 24 and older, up to 99. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age: > 24 years
• Male / Female not meeting any of the exclusion criteria

You may not qualify if…

• Age < 24 years
• Current use of antidepressant medications (including SSRI/SNRI, tricyclic, or Monoamine Oxidase Inhibitors)
• History of seizure disorder
• Diagnosis of bipolar disorder
• History of syncope/orthostatic hypotension
• Diagnosis of any condition with slowed gastric emptying
• History of suicidal ideation
• History of liver disease
• History of chronic kidney disease/renal impairment
• History of angle-closure glaucoma.

Where it is running

• Scripps Clinic Torrey Pines — La Jolla, California, United States

Full record on ClinicalTrials.gov

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