Comparing Intubation Rates in the Delivery Room by Interface
Status unconfirmed
Conditions studied: Ventilator Lung; Newborn
In brief
Although the majority of premature neonates \< 30 weeks gestion require positive pressure ventilation (PPV) at birth, the optimal interface to provide PPV has not been determined. Preferably this support would be provided by non-invasive means to prevent the development of bronchopulmonary dysplasia. Resuscitation with a face mask, single nasal tube, nasal prongs, and/or LMA are all approved methods of resuscitation per NRP as of 2010. Face masks have been associated with more dead space, air leak and airway obstruction however are the most commonly used interface. Recently, the Trigeminal Cardiac Reflex has been described, which can be induced with the placement of a facemask, resulting in bradycardia and apnea. Bi-nasal prongs (RAM cannula) have been found in studies to be associated with lower intubation rates in the delivery room (down to 24 weeks gestation), less need for epinephrine, chest compressions, and subsequent invasive ventilation. In addition to the potential practical advantages of bi-nasal prong resuscitation, there is evidence to suggest that ventilation through the nose may stimulate the subepithelial receptors of the upper airways causing an increase in respiratory rate and depth.
Key facts
- Study ID
- NCT05609773
- Run by
- University of Illinois College of Medicine at Peoria
- People needed
- 42
- Starts
- 2022-09-22
- Expected to finish
- 2025-09-22
- Last updated by the study team
- 2022-12-20
Who can join
Age: any, up to 1. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All resuscitated infants < 30 weeks' gestation born at OSF SFMC
You may not qualify if…
- Diagnosis of congenital diaphragmatic hernia No PPV needed, or no resuscitation desired due to major congenital anomalies or peri- viable status
Where it is running
- University of Illinois College of Medicince — Peoria, Illinois, United States (enrolling)
Full record on ClinicalTrials.gov
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