Evaluation of Lower Extremity Athletic Injuries and Response to Treatment Using SWE and MFI

Completed · Not applicable

Conditions studied: Lower Extremity Musculoskeletal Injury

In brief

Primary Objective: To explore changes in shear wave elastography (SWE) and microvascular flow imaging (MFI) measurements from time of injury through the recovery phase of lower extremity musculoskeletal injuries to determine if a correlation exists with functional impairment. Secondary Objective: To develop a deep learning AI system for automated region of interest (ROI) determination for measurement of average SWE and MFI. Methodology: Eligible subjects with lower extremity injuries will undergo SWE and MFI measurements and complete the Lower Extremity Functional Scale questionnaire at each study visit. Clinical data related to the evaluation of the injury acquired during standard medical care of the injury will be collected from the patients' medical record such as CT or MRI scans, X-rays, physical exams and tests as well as laboratory measurements. Subjects will undergo serial SWE and MFI imaging throughout their rehabilitation episode of care to assess changes over time, status in rehabilitation and comparison to the contralateral extremity.

Key facts

Study ID

NCT05608824

Run by

Oregon Health and Science University

People needed

9

Starts

2023-10-01

Expected to finish

2025-09-30

Last updated by the study team

2026-04-07

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects age 18 - 89 years;
• Able to sign an informed consent document;
• Suspected MSK injury of the lower extremity (i.e. hamstring injuries and soft tissue injuries involving the ankle).

You may not qualify if…

• Prior fasciotomy of same limb;
• Hemodialysis grafts of involved extremity;
• Extremity wounds preventing ultrasound imaging.

Where it is running

• University of Oregon — Eugene, Oregon, United States
• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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