A Novel Limb Cryocompression System for Prevention of Chemotherapy Induced Peripheral Neuropathy - Expansion Study

Recruiting now · Not applicable

Conditions studied: Chemotherapy-induced Peripheral Neuropathy

In brief

The study conducted on cancer patients is designed to test safety and efficacy of limb hypothermia in cancer patients using the new Paxman Limb Cryocompression System (PLCS). Ultimately this will lead to the development of a therapy regime that will help to prevent chemotherapy-induced neuropathy in cancer patients.

Key facts

Study ID

NCT05606068

Run by

National University Hospital, Singapore

People needed

200

Starts

2022-11-11

Expected to finish

2026-11-01

Last updated by the study team

2026-06-22

Who can join

Age: 21 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 21- 80 years.
• Signed informed consent from patient or legal representative
• Scheduled to receive weekly paclitaxel chemotherapy
• Patients may receive other chemotherapy drugs alongside taxane e.g. Platinum/Herceptin.

You may not qualify if…

• Open skin wound or ulcers of the limbs
• History of Raynaud's phenomenon, peripheral vascular disease, or poorly controlled diabetes
• Pregnant woman
• A score of more than 5 in Total Neuropathy Score (TNS) at baseline for cancer patients

Where it is running

• National University Hospital — Singapore, Singapore (enrolling)
• Curie Oncology, Mount Elizabeth Novena Specialist Centre — Singapore, Singapore

Full record on ClinicalTrials.gov

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