Cardiac MRI-guided Deferiprone Therapy for Acute Myocardial Infarction Patients

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Acute Myocardial Infarction Type 1

In brief

The objective of this randomized, controlled pilot study is to determine the efficacy of Deferiprone to reduce the amount of free iron inside the hemorrhagic zone of myocardial infarction among hemorrhagic myocardial infarction patients.

Key facts

Study ID

NCT05604131

Run by

Rohan Dharmakumar

People needed

89

Starts

2022-11-08

Expected to finish

2029-08-31

Last updated by the study team

2026-04-08

Who can join

Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-79 years
• Index Anterior wall STEMI
• Emergency coronary angiogram with primary PCI

You may not qualify if…

• Prior history of MI / PCI / coronary artery bypass graft (CABG) within previous 1 year
• Patients with previous history of left ventricular ejection fraction (LVEF) < 40%
• Use of investigational drugs or devices 30 days prior to randomization
• Known allergy or contra-indication to gadolinium/contrast agents
• eGFR < 30 ml/kg/min
• Any contraindication against cardiac MRI (such as metal implants)
• Women who are pregnant or breastfeeding. Women of reproductive potential must have a negative pregnancy test prior to randomization
• Body weight > 140 kg (or 309 lbs.)
• Absolute neutrophil count - ANC < 1.5 k/cumm
• History of Chronic Liver Disease
• Elevated hepatic enzymes (BOTH ALT and AST) > 2 times of upper normal limit
• Patients with iron storage disease (hemochromatosis, thalassemia) or who are already treated with iron chelators
• Any clinically significant abnormality identified prior to randomization that in the judgment of the Sponsor-Investigator or Delegate would preclude safe completion of the study or confound the anticipated benefit of deferiprone.
• Life expectancy of less than 1 year due to non-cardiac pathology

Where it is running

• IU Methodist Hospital (IUHealth) — Indianapolis, Indiana, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.