TA-65 and Aging Associated Microvascular Dysfunction
Starting soon · Not applicable · Has a placebo group
Conditions studied: Telomere Shortening, Aging, Vascular Diseases
In brief
The goal of this clinical trial is to test whether activation of telomerase with a dietary supplement (TA-65) improves microvascular function.
Key facts
- Study ID
- NCT05598359
- Run by
- Medical College of Wisconsin
- People needed
- 180
- Starts
- 2027-01-01
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2026-05-01
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy Adults 18 - 35 and 65+ years of age
- Subjects with clinical diagnosis of CAD
- Exclusion criteria will include:
- 36-64 years of age without clinical diagnosis of CAD
- Self-reported habitual vigorous exercise (>20 min, 3 times per week, 1 yr)
- Major Adverse Cardiovascular Event (MACE) in the last year (heart attack, stroke)
- Heart Failure
- Renal Impairment
- >3 Pre-existing Cardiovascular Risk Factors (healthy groups only)
- Type 1 or type 2 diabetes
- Uncontrolled hypertension
- Current tobacco use or within last 6 months
- BMI > 35
- Hyperlipidemia
- Hypercholesterolemia
- Use of anti-coagulant drugs
- Use of anti-platelet drugs
- Erectile dysfunction medication in the past 6 months
- Use of topical/non-topical steroids in last 6 months
- Hormone replacement therapy (Post-Menopause or Gender Reassignment)
- History of retinopathy
- Documented neuromuscular disorders
- Porphyria Cutanea Tarda (blistering of skin to sun; photosensitivity)
- Pregnancy (young female subjects)
- Allergy to lidocaine
Full record on ClinicalTrials.gov
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