Shanghai At Risk for Alzheimer's Disease: a Cohort Study
Recruiting now
Conditions studied: Alzheimer Disease, Dementia, Neurodegenerative Diseases, Cognitive Impairment, Neurocognitive Disorders
In brief
The goal of this cohort study is to estimate the incidence of AD in the first-degree relatives of patients with AD. The main questions it aims to answer are: * cognitive changes of subjects at high risk of AD as ageing; * environmental and behavioral factors affecting AD incidence.
Key facts
- Study ID
- NCT05597410
- Run by
- Ruijin Hospital
- People needed
- 3418
- Starts
- 2022-03-01
- Expected to finish
- 2030-03-01
- Last updated by the study team
- 2022-10-28
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- the AD diagnostic criteria of probands meet the 2011 National Institute on Aging - Alzheimer's Association framework, and participants are the first-degree relatives (including parents, children and siblings of the same father and mother) of the proband;
- not patients with dementia;
- ≥ 50 years, males and females;
- subjects have lived in Shanghai for more than 1 year and have no plan to move out of Shanghai within 5 years;
- subjects are able to complete investigation, physical examination, imaging examination and biological specimen collection.
You may not qualify if…
- Individuals will be excluded if they have:
- other diseases which could cause cognitive decline, e.g. cerebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease;
- history of psychological disorders (according to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition);
- uncorrectable visual or auditory impairment that hampers the completion of related examination.
- pre-menopausal women will also be excluded.
Where it is running
- Ruijin Hospital, Shanghai Jiao Tong University School of Medicine — Shanghai, Shanghai Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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