Prospective, Longitudinal, Observational Registry of Adult Patients With Hypophosphatasia (REG-HYPO)

Recruiting now

Conditions studied: Hypophosphatasia

In brief

The purpose of this study is to assess medical events during follow-up of adult patients having hypophosphatasia and consulting rheumatologists.

Key facts

Study ID

NCT05596539

Run by

Assistance Publique - Hôpitaux de Paris

People needed

200

Starts

2023-03-22

Expected to finish

2031-09-01

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• men and women,
• aged 18 and over, with no upper age limit, who have had a total alkaline phosphatase value of less than 40 IU/l on at least 3 occasions, or at least a total alkaline phosphatase value below 40 IU/L and evidence of ALPL gene polymorphism
• with at least one rheumatological symptom.

You may not qualify if…

• transient hypophosphatasia: absence of confirmation of a value below 40 IU/l on at least 3 samples, lack of genetic confirmation
• secondary hypophosphatasia according to the expert rheumatologist (drugs, endocrine disease, other genetic disease...).

Where it is running

• CHU de Bordeaux- Hôpital Pellegrin Place Amélia Raba Léon - 12è étage - Rhumatologie - — Bordeaux, France, France (enrolling)
• CHU Lille — Lille, France (enrolling)
• Hospices Civils de Lyon — Lyon, France (enrolling)
• CHU Nice — Nice, France (enrolling)
• Lariboisière Hospital — Paris, France (enrolling)
• Cochin Hospital — Paris, France (enrolling)
• CHU Poitiers — Poitiers, France (enrolling)
• CHU Rennes — Rennes, France (enrolling)
• CHU Saint-Etienne — Saint-Priest-en-Jarez, France (enrolling)
• Les hôpitaux universitaires de Strasbourg — Strasbourg, France (enrolling)
• CHU de Toulouse — Toulouse, France (enrolling)

Full record on ClinicalTrials.gov

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